Data from the Mayo Clinic trial in primary biliary cirrhosis (PBC) of the
liver. This dataset was obtained from the survival package:
the variables copper and trig from survival::pbc were
merged into survival::pbcseq and several categorical variables were
re-coded.
PBC: A data frame of 312 individuals in long format with 1945 rows
and 21 variables.
case number
number of days between registration and the earlier of death, transplantation, or end of follow-up
status at endpoint ("censored", "transplant" or "dead")
D-pen (D-penicillamine) vs placebo
in years
male or female
urine copper (\(\mu\)g/day)
triglycerides (mg/dl)
number of days between enrolment and this visit date; all measurements below refer to this date
serum albumin (mg/dl)
alkaline phosphatase (U/liter)
presence of ascites
aspartate aminotransferase (U/ml)
serum bilirubin (mg/dl)
serum cholesterol (mg/dl)
"no": no oedema, "(un)treated": untreated or successfully treated 1 oedema, "edema": oedema despite diuretic therapy
presence of hepatomegaly (enlarged liver)
platelet count
standardised blood clotting time
blood vessel malformations in the skin
histologic stage of disease (4 levels)
summary(PBC)
#> id futime status trt age
#> Min. : 1.0 Min. : 41 censored :1073 D-pen :967 Min. :26.28
#> 1st Qu.: 61.0 1st Qu.:2055 transplant: 147 placebo:978 1st Qu.:41.79
#> Median :126.0 Median :2963 dead : 725 Median :48.87
#> Mean :135.4 Mean :2941 Mean :49.26
#> 3rd Qu.:203.0 3rd Qu.:3819 3rd Qu.:56.15
#> Max. :312.0 Max. :5225 Max. :78.44
#>
#> sex day ascites hepato spiders
#> male : 237 Min. : 0 no :1716 no :952 no :1311
#> female:1708 1st Qu.: 192 yes : 169 yes :932 yes : 576
#> Median : 750 NA's: 60 NA's: 61 NA's: 58
#> Mean :1145
#> 3rd Qu.:1838
#> Max. :5152
#>
#> edema bili chol albumin
#> no :1401 Min. : 0.100 Min. : 55.0 Min. :1.17
#> (un)treated: 379 1st Qu.: 0.800 1st Qu.: 235.0 1st Qu.:3.11
#> edema : 165 Median : 1.400 Median : 281.0 Median :3.44
#> Mean : 3.672 Mean : 320.5 Mean :3.39
#> 3rd Qu.: 3.900 3rd Qu.: 349.2 3rd Qu.:3.70
#> Max. :41.000 Max. :1775.0 Max. :8.01
#> NA's :821
#> alk.phos ast platelet protime stage
#> Min. : 73 Min. : 6.2 Min. : 40.0 Min. : 9.0 1: 95
#> 1st Qu.: 737 1st Qu.: 72.0 1st Qu.:165.0 1st Qu.:10.1 2:266
#> Median : 1072 Median : 107.0 Median :228.0 Median :10.8 3:612
#> Mean : 1382 Mean : 122.7 Mean :233.7 Mean :11.0 4:972
#> 3rd Qu.: 1636 3rd Qu.: 155.0 3rd Qu.:290.2 3rd Qu.:11.5
#> Max. :13862 Max. :1205.0 Max. :991.0 Max. :36.0
#> NA's :60 NA's :73
#> copper trig
#> Min. : 4.00 Min. : 33
#> 1st Qu.: 38.00 1st Qu.: 83
#> Median : 65.00 Median :105
#> Mean : 84.54 Mean :122
#> 3rd Qu.:105.00 3rd Qu.:151
#> Max. :588.00 Max. :598
#> NA's :8 NA's :206