# EP16: Missing Values in Clinical Research

## Multiple Imputation

This website contains materials for the NIHES course Missing Values in Clinical Research (EP16):

• lecture slides
• practicals

The practicals require R, and JAGS (necessary for the parts of the practical that use the JointAI package) needs to be installed.

## Software

The practicals require R, and JAGS (necessary for the parts of the practical that use the JointAI package) needs to be installed.

### R

It is strongly recommended to use a recent version of R, i.e., version 4.0.0 or later.

To check the version number of R, you can use the following syntax (in R):

R.version.string

### JAGS

The JAGS version should be 4.2.0 or later.

### R packages

You will also need the following R packages:

install.packages("mice")
install.packages("JointAI")
install.packages("ggplot2")
install.packages("corrplot")

For the packages mice and JointAI it is important that you have recent versions installed.

• mice version 3.8.0 or later
• JointAI version 0.6.1

To check which version of a package you have installed, you can use the function packageVersion(), for example

packageVersion("JointAI")
packageVersion("mice")

Once you have the package JointAI installed1, you can use the following syntax to check if R can find JAGS, and which version of JAGS is installed:

rjags::jags.version()

There are a number of additional packages that may be useful:

install.packages("VIM")
install.packages("naniar")
install.packages("visdat")

1: This function is not actually part of JointAI, but of the package rjags. Since JointAI depends on rjags, rjags will be installed automatically with JointAI.